Oleanane-type triterpenoid: an anti-inflammatory compound of the roots Arrabidaea brachypoda
AUTOR(ES)
Rocha, Cláudia Q. da, Vilela, Fabiana C., Santa-Cecília, Flávia V., Cavalcante, Gustavo P., Vilegas, Wagner, Giusti-Paiva, Alexandre, Santos, Marcelo H. dos
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
2015-06
RESUMO
AbstractArrabidaea brachypoda Bureau, Bignoniaceae, known as "cipó-una", is widely used in traditional medicine in Southeastern and Northeastern Brazil for kidney stones and painful joints. This study was aimed at evaluating the anti-inflammatory proprieties of the oleanane-type triterpenoid 3β-estearioxy-olean-12-ene isolated from the roots of A. brachypoda. Carrageenan-induced paw oedema, formalin test and hot plate test were used to investigate the antiinflammatory activity of 3β-estearioxy-olean-12-ene in animals. We observed that 3β-estearioxy-olean-12-ene at doses of 5, 10 and 15 mg/kg p.o. demonstrated anti-inflammatory effects, by reduced (p < 0.05) paw oedema induced by carrageenan and by decreased (p < 0.05) licking time caused by a subplantar injection of formalin. In conclusion, 3β-estearioxy-olean-12-ene, a triterpene isolated from the roots of A. brachypoda, demonstrate anti-inflammatory effect in different tests. Thus, it may be useful in the treatment of inflammatory disorders, which supports previous claims of its traditional use.
