Novel variants of human herpesvirus 2 from Brazilian HIV-1 coinfected subjects

AUTOR(ES)

Lima, Lyana Rodrigues Pinto, Araújo, Nathália Alves de, Guterres, Alexandro, Pilotto, José Henrique, Niel, Christian, Paula, Vanessa Salete de

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

03/12/2018

RESUMO

BACKGROUND Human herpesvirus 2 (HHV-2) have DNA genome with a limited genetic variability and have been classified into two clades. OBJECTIVES To identify and characterise six HHV-2 isolates derived from Brazilian women. METHODS HHV-2 isolates were performed polymerase chain reaction (PCR) and sequencing of 2250 pb of the glycoprotein B (gB) coding regions. FINDINGS Four HHV-2 isolates were classified into clade B, while the remaining two, derived from HIV-1 co-infected women, showed a notable genetic divergence (> 1%). MAIN CONCLUSION The results reveal novel HHV-2 variants. The impact of these novel variants on HHV-2 pathogenesis and HIV/HHV-2 coinfection need to be investigated.

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