Nonimmune Interaction of the SfbI Protein of Streptococcus pyogenes with the Immunoglobulin G F(ab′)2 Fragment

AUTOR(ES)

Medina, Eva

FONTE

American Society for Microbiology

RESUMO

Fibronectin-binding protein I (SfbI) of Streptococcus pyogenes binds to mouse immunoglobulin G (IgG) but not to IgA or IgM in a nonimmune fashion. The fibronectin-binding domains of SfbI were responsible for this activity, which was targeted to the IgG F(ab′)2 fragment. SfbI also binds to B cells but not to CD4+ or CD8+ lymphocytes.

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