N-Acetylcysteine Inhibits Post-Impact Chondrocyte Death in Osteochondral Explants
AUTOR(ES)
Martin, James A.
FONTE
Journal of Bone and Joint Surgery
RESUMO
Background: Chondrocyte death has been linked to injury-induced oxidative damage, suggesting that antioxidants could substantially improve viability. However, since reactive oxygen species play roles in normal physiology, there are concerns that antioxidants may have deleterious side effects. To address these issues, we studied the effects of N-acetylcysteine, a potent free radical scavenger, on chondrocyte viability and cartilage proteoglycan content in an in vitro cartilage injury model. We hypothesized that treatment with N-acetylcysteine soon after an impact injury would have significant chondrocyte-sparing effects and would prevent injury-induced proteoglycan losses.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2714809Documentos Relacionados
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