Multiple viral core proteins are determinants of reovirus-induced acute myocarditis.

AUTOR(ES)

Sherry, B

RESUMO

Previously, we showed that the M1 gene (encoding a viral core protein, mu 2, whose function is unknown) was associated with the efficiently myocarditic phenotype of a reovirus variant, 8B. Here, we have extended our genetic analysis of 8B and conducted genetic analyses of two other reovirus strains (T1L [serotype 1 strain Lang] and Abney). Our results demonstrate that multiple viral core proteins are determinants of reovirus-induced myocarditis. In contrast to our previous association of mu 2 with induction of myocarditis, this provides strong evidence that a core function achieved through the interaction of multiple core proteins is responsible for induction of the disease.

Documentos Relacionados

• Lymphocytes protect against and are not required for reovirus-induced myocarditis.
• Cytopathogenic effect in cardiac myocytes but not in cardiac fibroblasts is correlated with reovirus-induced acute myocarditis.
• Reovirus-induced acute myocarditis in mice correlates with viral RNA synthesis rather than generation of infectious virus in cardiac myocytes.
• Reovirus-induced Ribonucleic Acid Polymerase
• Reovirus-Induced Apoptosis Is Mediated by TRAIL