Moxalactam pharmacokinetics during hemodialysis.
AUTOR(ES)
Aronoff, G R
RESUMO
To establish dosage recommendations, moxalactam elimination kinetics were studied in six anephric patients during hemodialysis and in four anephric patients during the interdialytic period. After a single 1-g intravenous bolus injection, moxalactam elimination half-life was 18.0 plus or minus 0.6 h with a volume of distribution of 20.2 plus or minus 3.6 liters and a plasma clearance of 12.8 plus or minus 2.0 ml/min in four nondialyzed patients. Moxalactam elimination half-life was decreased to 2.7 plus or minus 0.2 h during hemodialysis in six patients. After 4 h, 48.5% of the dose was recovered in the dialysate. The maintenance dose of moxalactam should be decreased to 15% of a normal dose in patients with creatinine clearances less than 10 ml/min, and 50% of a loading dose should be given after hemodialysis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=181480Documentos Relacionados
- Pharmacokinetics of moxalactam in patients with renal failure and during hemodialysis.
- Pharmacokinetics of intravenous piperacillin in patients undergoing chronic hemodialysis.
- Pharmacokinetics of fleroxacin after multiple oral dosing in patients receiving regular hemodialysis.
- Pharmacokinetics of cefaclor in renal failure: effects of multiple doses and hemodialysis.
- Pharmacokinetics of ceforanide in patients with end stage renal disease on hemodialysis.