Monitoring ibuprofen release from multiparticulates: In situ fiber-optic technique versus the HPLC method: A technical note

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Springer-Verlag

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The results from the linearity test showed that the automated FOPS method was linear and reproducible in predicting ibuprofen concentrations, as was shown by a high R2 and low %RSD over a range of concentrations. Second-derivative treatment of the UV spectrum makes it possible to remove the effects of the sloping baseline often encountered in spectra of highly turbid samples. The dissolution profiles obtained by FOPS were more accurate with lower and consistent %RSD as compared with the HPLC method, particularly in the case of immediate-release multiparticulates. The FOPS method was also faster and less labor intensive.

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