Modulação da resposta imune a aloantígenos por células-tronco derivadas do tecido adiposo / Modulation of Immune alloresponse by Adiposetissue Derived Mesenchymal Stem Cells

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The identification and characterization de regulatory T cells that can control immune responsiveness to alloantigens opened up opportunities for new therapies in transplantation. After exposure to alloantigens in vivo, antigen-specific immunoregulatory activity is enriched in a population of CD4+ T cells that express high levels of CD25 and Foxp3. Adipose tissue contains one type of mesenchymal stem cells (ADSC) with capacity of suppressing immune response. In this work we propose the correlation of the ADSC cells in ameliorating skin graft survival, and if is associated with Foxp3 expression. Graft survival was enhanced in animals that received ASCs from the donor. Interesting, in the animals treated with ASCs from CBA presented a higher expression of Foxp3+ cells in the lymph-nodes. In treated mice Foxp3 expression was increased and IL-17 were increased in allogeneic group, suggesting a potent inflammatory response inside the graft. So far, these data suggest the ADSCs increase TReg population cells, inhibit IL-17 expression and prolonging skin graft survival.

ASSUNTO(S)

linfócitos t t lymphocytes imunoterapia interleucinas skin transplantation transporte de pele stem cells immunotherapy imunossupressão interleukin células- tronco immunosuppression

ACESSO AO ARTIGO

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