MICROEMULSION OF BRAZIL NUT OIL AS A NATURAL PRODUCT TO IMPROVE SUPEROXIDE RELEASE IN HUMAN PHAGOCYTES
AUTOR(ES)
Fiori, Karol Patel, Torres, Maycon de Paula Ribeiro, Schons, Jessica Iara, Ribeiro, Elton Brito, Nogueira, Roberta Martins, Vasconcelos, Leonardo G., Andrighetti, Carla R., Jacinto, Marcos José, Valladão, Denia M. de S.
FONTE
Quím. Nova
DATA DE PUBLICAÇÃO
2017-09
RESUMO
The aim of this study was to develop and characterize a Brazil nut oil microemulsion system and determine the effect of this microemulsion on the superoxide release in human phagocytes. The microemulsion was formulated using distilled water, Brazil nut as the oily phase, Sorbitan monooleate, Polysorbate 80, and butan-1-ol. Hydrophile-lipophile balance of Brazil nut oil was determined, pseudoternary diagrams were prepared, and microemulsion diagram regions were preselected. Preliminary and accelerated stability tests, rheological characterization and dynamic light scattering were performed. The immunomodulatory effect of the microemulsion on the interactions with leukocytes was determined by superoxide release. The developed formulations were classified as oil-in-water, showed a Newtonian profile, with linear viscosity and droplet sizes of 46.9; 66.5 and 34.3 nm. When we assessed the interaction of the microemulsion of Brazil nut oil with phagocytes, we observed an increase in superoxide release. Our findings indicate that the developed formulation improved the immunomodulatory activity of the Brazil nut oil, proving to be a natural product option for future applications, in particular for infectious diseases.
Documentos Relacionados
- Enhanced superoxide anion release from phagocytes by muramyl dipeptide or lipopolysaccharide.
- Effect of vegetable oil (Brazil nut oil) and mineral oil (liquid petrolatum) on dental biofilm control
- DNA release as a direct measure of microbial killing by phagocytes.
- Brazil Nut Oil Extraction Using Subcritical n-Propane: Advantages and Chemical Composition
- Detailed study of Brazil nut (Bertholletia excelsa) oil micro-compounds: phospholipids, tocopherols and sterols