Pleasant memories: remembering immune protection while forgetting about graft-versus-host disease
AUTOR(ES)
Sondel, Paul M.
FONTE
American Society for Clinical Investigation
RESUMO
Graft-versus-host disease (GVHD) represents a major cause of morbidity and mortality following conventional allogeneic hematopoietic stem cell transplantation (HSCT). A study in mice (see related article on pages 101–108) demonstrates that the selective administration of donor memory CD4+ T cells results in immune reconstitution without GVHD, a result that, if translatable to humans, has important clinical implications for HSCT.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=162299Documentos Relacionados
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