Melanoma cells resistant to inhibition of growth by melanocyte stimulating hormone.
AUTOR(ES)
Pawelek, J
RESUMO
Melanocyte stimulating hormone (MSH) enhances melanization but inhibits proliferation of Cloudman S91 melanoma cells in culture. We have isolated variants of these cells that can grow in the presence of MSH. The conclusions we have reached from analyses of these cells are the following: (1) Basal tyrosinase activity (monophenol monooxygenase; monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, EC 1.14.18.1), i.e., the activity that is present in the absence of added MSH, is related through a common biochemical pathway to MSH-mediated control of growth. (2) MSH-inducible tyrosinase activity does not appear to be related to MSH control of growth. (3) The morphological changes that occur following the addition of MSH or cAMP are related to controls of growth and not to those of melanization.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=432441Documentos Relacionados
- Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone.
- The experimental generation of antibodies to alpha-melanocyte stimulating hormone and adrenocorticotropic hormone.
- Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone.
- Cholera Toxin Mimics Melanocyte Stimulating Hormone in Inducing Differentiation in Melanoma Cells
- Inhibition of growth of human mammary tumor cells by potent antagonists of luteinizing hormone-releasing hormone.
