Mechanisms of ventilator-induced lung injury: the clinician's perspective
AUTOR(ES)
Michaud, Gaëtane
FONTE
BioMed Central
RESUMO
In the present issue of Critical Care, Frank and Matthay review the physiologic mechanisms that lead to ventilator-induced lung injury. Our greater understanding of basic physiologic principles has already had a major impact on the treatment of critically ill patients. Novel strategies to limit ventilator-induced lung injury have now been shown to improve survival. However, there has been debate in the literature regarding the safety and efficacy of the Acute Respiratory Distress Syndrome (ARDS) Network study protocol in reducing ventilator-induced lung injury. The issues surrounding the ARDS Network protocol and a recent meta-analysis criticizing its use are presented. As clinicians, we now have the responsibility to ensure that our patients benefit from these recent developments.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=270666Documentos Relacionados
- Science review: Mechanisms of ventilator-induced injury
- Hypercapnia attenuates ventilator-induced lung injury through vagus nerve activation
- Role of the renin‐angiotensin system in ventilator‐induced lung injury: an in vivo study in a rat model
- Bench-to-bedside review: Microvascular and airspace linkage in ventilator-induced lung injury
- Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury