Marine Pseudomonas putida: a potential source of antimicrobial substances against antibiotic-resistant bacteria

AUTOR(ES)

Marinho, Palloma Rodrigues, Moreira, Ana Paula Barbosa, Pellegrino, Flávia Lúcia Piffano Costa, Muricy, Guilherme, Bastos, Maria do Carmo de Freire, Santos, Kátia Regina Netto dos, Giambiagi-deMarval, Marcia, Laport, Marinella Silva

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2009-08

RESUMO

Bacteria isolated from marine sponges found off the coast of Rio de Janeiro, Brazil, were screened for the production of antimicrobial substances. We report a new Pseudomonas putida strain (designated P. putida Mm3) isolated from the sponge Mycale microsigmatosa that produces a powerful antimicrobial substance active against multidrug-resistant bacteria. P. putida Mm3 was identified on the basis of 16S rRNA gene sequencing and phenotypic tests. Molecular typing for Mm3 was performed by RAPD-PCR and comparison of the results to other Pseudomonas strains. Our results contribute to the search for new antimicrobial agents, an important strategy for developing alternative therapies to treat infections caused by multidrug-resistant bacteria.

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