Major Histocompatibility Complex-Dependent Susceptibility to Cryptococcus neoformans in Mice
AUTOR(ES)
McClelland, Erin E.
FONTE
American Society for Microbiology
RESUMO
To evaluate the role of major histocompatibility complex (MHC) genes in the resistance to Cryptococcus neoformans, we conducted infection experiments in MHC-congenic strains of mice. Significant MHC-dependent susceptibility differences were found among homozygotes and heterozygotes. This study is the first experimental demonstration of MHC-dependent susceptibility to C. neoformans infections in mice and indicates that MHC genes can be important in host resistance.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=166009Documentos Relacionados
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