Low frequency of hypersensitivity reactions to abacavir in HIV infected patients in a referral center in Bahia, Brazil
AUTOR(ES)
Barreto, Raphael Gusmão
FONTE
Braz J Infect Dis
DATA DE PUBLICAÇÃO
24/10/2019
RESUMO
Abstract Abacavir can cause a multi-systemic hypersensitivity reaction (HSR) in 5-8% of the patients, which is related to HLA-B*57-01 allele. In Brazil, the HLA-B*57-01 screening test became available only in March 2018, several years after abacavir was in use. In this retrospective study we reviewed medical charts of all patients receiving an abacavir-containing regimen to evaluate the frequency of HSR in patients followed at a referral center in Salvador, Brazil. A total of 192 patients who received abacavir were identified, most male (67.1%), black or racially mixed (77.8%), and having diagnosis of a previous AIDS defining conditions (83.7%). Only one patient developed HSR (incidence: 0.52%). The main reasons for abacavir-containing antiretroviral therapy discontinuation were virological failure (28%), adverse effects to other components of the regimen (25%), and simplification of therapy (16%). The low incidence of HSR to abacavir does not support the use of HLA-B*57-01 screening test, in Salvador, Brazil.
Documentos Relacionados
- High prevalence of giardiasis and strongyloidiasis among HIV-infected patients in Bahia, Brazil
- Frequency of HLA B*5701 allele carriers in abacavir treated-HIV infected patients and controls from northeastern Brazil
- Prevalence of HIV infection in patients hospitalized for tuberculosis in Bahia, Brazil
- Frequency of mental disturbances in HTLV-1 patients in the state of Bahia, Brazil
- Hepatitis C virus infection and spontaneous clearance in HTLV-1 and HIV co-infected patients in Salvador, Bahia, Brazil