Loss of Werner syndrome protein function promotes aberrant mitotic recombination
AUTOR(ES)
Prince, Polly R.
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
The chromosome 8p11–12 Werner syndrome (WRN ) locus encodes a RecQ helicase protein of unknown function that possesses both 3′ → 5′ helicase and 3′ → 5′ exonuclease activities. We show that WRN cell lines display a marked reduction in cell proliferation following mitotic recombination, and generate few viable gene conversion-type recombinants. These findings indicate that WRN plays a role in mitotic recombination, and that a loss of WRN function may promote genetic instability and disease via recombination-initiated mitotic arrest, cell death, or gene rearrangement.
