Liquid-phase microextraction for simultaneous chromatographic analysis of three antidepressant drugs in plasma

AUTOR(ES)

Porto, Carlos Eduardo Dobrovolskni, Maia, Patrícia Penido, Freitas, Daniela Fernanda de, Araújo, Rafhaella Carolina Cedro, Siqueira, Maria Elisa Pereira Bastos de, Martins, Isarita, Santos-Neto, Álvaro José dos

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2012

RESUMO

A method using Liquid Phase Microextraction for simultaneous detection of citalopram (CIT), paroxetine (PAR) and fluoxetine (FLU), using venlafaxine as internal standard, in plasma by high performance liquid chromatography with fluorescence detection was developed. The linearity was evaluated between 5.0 and 500 ng mL-1 (r > 0.99) and the limit of quantification was 2.0, 3.0 and 5.0 ng mL-1 for CIT, PAR and FLU, respectively. Therefore, it can be applied to therapeutic drug monitoring, pharmacokinetics or bioavailability studies and its advantages are that it necessary relatively inexpensive equipment and sample preparation techniques.

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