Lipid profile in adolescence: the effect of prenatal exposures and newborn, the 1982 birth cohort, Pelotas, Brazil / Perfil lipídico na adolescência : efeito de exposições pré-natais e neonatais, coorte de nascimentos de 1982, Pelotas, Brasil

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

2008

RESUMO

This study assessed the effects of intrauterine growth restriction (IUGR) and prenatal variables related to fetal growth on blood lipids in adolescence. All hospital births taking place in 1982 in Pelotas were identified and this population has been followed-up since then. All male subjects were identified in 2000 when enrolling in the national army; 79% (n = 2250) were traced and 2089 blood samples were made available. The following outcome variables were studied: Total cholesterol and fractions (VLDL, LDL, and HDL), non-HDL cholesterol, LDL/HDL ratio and serum triglycerides. The explanatory variables were IUGR, maternal pre-pregnancy body mass index (BMI) and maternal smoking during pregnancy. After adjusting for confounding variables, total and LDL cholesterol levels were slightly and significantly higher among adolescents whose mothers were in the 3rd and 4th quartile of pre-pregnancy BMI. However, these associations disappeared after adjusting for adolescents diet, schooling and BMI. A similar relation was observed for non-HDL cholesterol. Other associations were not significant (p>0.05). A higher maternal pre-pregnancy BMI seems to have an influence on the lipid profile of their offspring. Yet, this association is mediated by current BMI.

ASSUNTO(S)

colesterol restrição de crescimento intra-uterino imc prégestacional fumo materno estudo de coorte epidemiologia cholesterol intrauterine growth restriction pre-pregnancy bmi maternal smoking adolescents cohort study

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