Likelihood Analysis of Recombinational Disequilibrium in Multiple-Locus Gametic Frequencies
AUTOR(ES)
Smouse, Peter E.
RESUMO
Likelihood methods are developed for the estimation and testing of multiple-locus gametic disequilibria, using log-linear models of parametric effects. The estimates of disquilibrium are related to Kimura's Z-measure, and may be extended to multiple alleles and multiple loci. Likelihood ratio test criteria are constructed, which are asymptotically distributed as χ2. The analysis is partitioned into various components corresponding to two-locus, residual three-locus, and higher order disequilibria. A four-locus example from Hordeum vulgare L. is utilized to illustrate the analysis. Most of the multiple-locus disequilibrium is accounted for by two-locus effects, and closely linked loci show considerably more disequilibrium than unlinked loci. It is shown that all possible pairwise comparisons are not statistically independent.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1213085Documentos Relacionados
- Multiple-Locus Variable-Number Tandem Repeat Analysis Reveals Genetic Relationships within Bacillus anthracis
- Multiple-Locus Variable-Number Tandem Repeat Analysis Reveals Genetic Relationships within Bacillus anthracis
- Worldwide Genetic Relationships among Francisella tularensis Isolates Determined by Multiple-Locus Variable-Number Tandem Repeat Analysis
- Molecular typing of Argentinian Mycobacterium avium subsp. paratuberculosis isolates by multiple-locus variable number-tandem repeat analysis
- Strain Typing of Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii by Using Multiple-Locus Variable-Number Tandem Repeat Analysis