Langat Virus M Protein Is Structurally Homologous to prM
AUTOR(ES)
Holbrook, Michael R.
FONTE
American Society for Microbiology
RESUMO
Langat (LGT) virus M protein has been generated in a recombinant system. Antiserum raised against the LGT virus M protein neutralizes tick-borne encephalitis serocomplex flaviviruses but not mosquito-borne flaviviruses, indicating that the M protein is exposed on the surface of virions. The antiserum recognizes intracellular LGT virus prM/M and binds to prM and M in Western blots of whole-cell lysates and purified virus, respectively. These data suggest that the prM and M proteins are structurally similar under native conditions and support the hypothesis that the “pr” portion of prM facilitates proper folding of the M protein for expression on the virion surface.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=114893Documentos Relacionados
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