Karyotypic “state” as a potential determinant for anticancer drug discovery
AUTOR(ES)
Roschke, Anna V.
FONTE
National Academy of Sciences
RESUMO
Cancer is a genetic disease caused by genomic instability. In many cancers, this instability is manifested by chromosomal reconfigurations and karyotypic complexity. These features are particular hallmarks of the epithelial cancers that are some of the malignancies most resistant to long term control by current chemotherapeutic agents. We have asked whether we could use karyotypic complexity and instability as determinants for the screening of potential anticancer compounds. Using a panel of well characterized cancer cell lines, we have been able to identify specific groups of chemical compounds that are more cytotoxic toward the relatively more karyotypically complex and unstable panel members. Thus, we delineate an approach for the identification of “lead compounds” for anticancer drug discovery complementary to those that are focused at the outset on a given gene or pathway.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=549443Documentos Relacionados
- Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
- Natural products as new antimitotic compounds for anticancer drug development
- Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review
- Crystal structure of dihydropyrimidine dehydrogenase, a major determinant of the pharmacokinetics of the anti-cancer drug 5-fluorouracil
- Characterization of DNA topoisomerase I from Candida albicans as a target for drug discovery.