Isolation and identification of formononetin of João Pessoa-PB-Brazil red propolis, seasonal studies and evaluation of their biological activities / Isolamento e identificação de formononetina da propolis de João Pessoa - PB, estudo de sua sazonalidade e avaliação de suas atividades biologicas

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Propolis is a resinous substance produced by the honeybee Apis mellifera. Bees use propolis to seal holes and to protect the beehive. To produce propolis the honeybee uses resins of leaf buds and buds, resinous exudates and other parts of plant tissues. Propolis is used as a folk medicine since 3000 BC. Numerous biological properties have been found including antimicrobial, anti-inflammatory and cicatrizing (Marcucci, 1995, Khayyal et al., 1993). Recently, studies revealed that propolis also has antioxidant, hypotensive, anesthetic, anticancer, anti-HIV and anticariogenic activities. The Brazilian propolis is classified into 13 distinct groups according to their chemical composition, which is directly related to the plants used to collect resins and exudates. In this study, propolis of group 13 was chosen, as it shows high biological activity. In this thesis were analyzed the quantity of whole phenolic compounds and flavonoids content was analyzed in each sample of propolis group 13, collected in different beehives and in different seasons. Furthermore, it was tested the biological activities of each sample. In addition, formononetin (7-hydroxy-4¿methoxyisoflavone), the main isoflavonoid found in propolis group 13, was isolated and identified and its biological activity was analyzed. It was demonstrated that João Pessoa ¿ PB red propolis has great variations of phenolic compounds and flavonoids among honeybees and different seasons. It was showed that propolis with greater amount of phenolic compounds and flavonoids have better antimicrobial activity against Staphylococcus aureus and antiradical activity. It was demonstrated a method of formononetin extraction of red propolis group 13, and it was showed that this compound has high antimicrobial activity against Staphylococcus aureus and antiradical activity

ASSUNTO(S)

dalbergia ecastophyllum flavonoids isoflavonoids propolis vermelha formononetin red propolis formononetina isoflavonoides flavonoides

ACESSO AO ARTIGO

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