INTERBASE VIBRATIONAL COUPLING IN G:C POLYNUCLEOTIDE HELICES

AUTOR(ES)

Howard, F. B.

RESUMO

The carbonyl stretching vibrations of G and C residues undergo frequency changes when a helical complex is formed from nonordered G and C components. We have prepared a series of two-stranded G:C helices having chemical and isotopic (18O) substitutions which lead to variation of the observed vibrational frequencies. Infrared spectra of these helices clearly demonstrate that vibrational coupling occurs between the guanine and cytosine residues in the helix. As a result of this coupling through the hydrogen bonds, the two carbonyl bands undergo frequency shifts of equal magnitude and opposite sign, with mixing of G and C character in the observed interacted vibrations.

Documentos Relacionados

• Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells.
• Immunogenicity of herpes simplex virus glycoproteins gC and gB and their role in protective immunity.
• Herpes Simplex Virus Type 1 Glycoprotein gC Mediates Immune Evasion In Vivo
• Glycosylation of herpes simplex virus type 1 gC in the presence of tunicamycin.
• The Absence of Glycoprotein gL, but Not gC or gK, Severely Impairs Pseudorabies Virus Neuroinvasiveness