Interação dos sistemas renina-angiotensina e calicreina-cininas em modelo de hipertensão arterial: estudo da indução de receptores B1 de cininas no sistema cardiovascular. / Renin-angiotensin and kallikrein-kinin systems interationstudy of B1 receptor induction by angiotensin II.
AUTOR(ES)
Graziela Scalianti Ceravolo
DATA DE PUBLICAÇÃO
2008
RESUMO
We investigated whether angiotensin II (Ang II) infusion modulates in vivo the kinin B1 receptor (B1R) expression, the mechanisms involved in this process, the role of the B1R activation in aorta and the effect of B1R antagonism in vivo upon vascular hypertrophy and inflammation. Ang II induced hypertension in Wistar was not affected by treatments with apocynin or B1R antagonism. The aorta of hypertensive rats presents: B1R expression, increased superoxide anion and NF-kB activity and apocynin treatment reduced those parameters. The B1R agonist promoted endothelium and NO-dependent dilation in aorta of Ang II rats. The aorta of Ang II rats presented hypertrophy, increased MAPKs activity and interleukins expression and the B1R antagonism reduced those parameters. Those data indicated that Ang II can induce B1R expression in aorta and this receptor could participate in Ang II-induced vascular hypertrophy and inflammation.
ASSUNTO(S)
angiotensina ii hypertension angiotensina ii receptor b1 de cininas receptor b1 de cininas hipertensão
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