Insights into gliomagenesis: systems biology unravels key pathways
AUTOR(ES)
de Souza, Sandro J
FONTE
BioMed Central
RESUMO
Technological advances have enabled a better characterization of all the genetic alterations in tumors. A picture that emerges is that tumor cells are much more genetically heterogeneous than originally expected. Thus, a critical issue in cancer genomics is the identification of the genetic alterations that drive the genesis of a tumor. Recently, a systems biology approach has been used to characterize such alterations and find associations between them and the process of gliomagenesis. Here, we discuss some implications of this strategy for the development of new therapeutic and diagnostic protocols for cancer.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2784304Documentos Relacionados
- Complex networks: the key to systems biology
- Proteomic mapping provides powerful insights into functional myelin biology
- Paleomolecular biology unravels the evolutionary mystery of vertebrate UV vision
- Cell adhesion in vascular biology. New insights into integrin-ligand interaction.
- Regulation of Host Cell Transcriptional Physiology by the Avian Pneumovirus Provides Key Insights into Host-Pathogen Interactions