Influência dos genes HLA classe I na progressão para a Aids em indivíduos HIV positivos

AUTOR(ES)
FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

2012

RESUMO

The AIDS epidemic is characterized by an extreme heterogeneity in the clinical course of HIV-1 infection. Whereas some individuals progress to AIDS within three years after seroconversion, a small percentage, called long-term nonprogressors, remain asymptomatic and maintain stable T-CD4+ cell counts for more than 10 years. The role of HLA class I molecules, such as HLA-A and HLA-B, have been investigated to explain the differences observed on progression to AIDS. Recent studies have focused on the potential effect of non-classical HLA I genes, as HLA- G, since this molecule is involved in the suppression of immune responses against viral infections. In the present study, ninety-eight patients with well defined criteria of clinical progression to AIDS were selected, of which 48 subjects were classified as chronic progressors, 29 as long-term nonprogressors and 21 as rapid progressors. Our results support the role of HLA homozygous genotypes on rapid progression to AIDS as well as the protective effect of the HLA-A*3 allele in the progression of the infection. Furthermore, this is the first study that assessed the influence of the HLA-G polymorphisms 14bp insertion/deletion and +3142 G/C on AIDS progression and the results obtained indicate an important role of this molecule on AIDS progression. The absence of classical genetic markers related to rapid and long-term nonprogression to AIDS in this group of HIV-infected patients emphasizes the importance of study genetic diversity among different populations.

ASSUNTO(S)

hiv antígenos hla aids

ACESSO AO ARTIGO

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