Influência do polimorfismo do gene do CCR-5 na transmissão materno-infantil do HIV-1 / The influence of polymorphism of the CCR-5 gene in the maternal-infant transmission of HIV-1

AUTOR(ES)

Camila de Almeida Agustoni

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

03/10/2011

RESUMO

The main via of infection by Human Imunodeficiency Virus (HIV-1) in children is the maternal-infant transmission (MIT). Several factors can be associated to MIT of HIV- 1. It\ s believed that the homozygote individual to the allele CCR5-?32 are resistant to the infection of HIV-1. Considering that the role of the mechanisms involved are still controversial, specifically the one of polymorphism of genes associated to the infection of HIV-1, this study evaluates the influence of deletion of the gene CCR5 in the MIT of the infection by HIV-1. It has been evaluated 82 couples of mothers and children, being 56 couples in which haven\ t occurred MIT and 26 in which have occurred MIT of HIV-1. In the current casuistry, it hasn\ t been detected meaningful differences when compared the presence of deletion of the gene CCR5 in MIT, in mother and children\ s couples, but it has been observed that there is a predominance of the presence of deletion in the not infected children to the ones vertically infected. Related to the social-demographic data, the use of antiretroviral therapy in the gestation and labor was meaningfully associated to the protection of MIT of HIV-1 (p= 0,0001 e p= 0,014, respectively). Therefore, the promotion of interventions that reduce the maternal viral load are fundamental for the reduction of MIT of HIV-1. There are several strategies to prevent the MIT, thus, children are still infected, becoming evident that there is still a wide challenge of its prevention. In this context, the nursing can contribute with actions that involve the prenatal, labor and puerperium, advising about the realization of the test of anti-HIV, the usage of antiretrovials, promotion and support of ideal practices of infant nourishment.

ASSUNTO(S)

ccr-5 ccr-5 hiv hiv-1 maternal-infant transmission (mit) transmissão materno-infantil (tmi)

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