Influencia das variações posturais sobre as forças hemodinamicas e a sua correlação com a espessura intima-media das arterias carotidas e popliteas / Postural changes, hemodynamics forces and correlation with intima-media thickness of carotid and popliteal arteries

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Atherosclerosis of peripheral arteries typically affects vessels of the lower limbs, suggesting that local hemodynamic stimuli play a role in this process. The present study evaluated the effects of body posture changes on carotid and popliteal circumferential wall tension (CWT) and investigated the relationship between local CWT and intima-media thickness (IMT) of these arteries. One hundred seventeen nondiabetic, nonhypertensive, nonsmoker subjects (48 men and 69 women) were evaluated. Blood pressure was measured in the arm and calf of subjects in supine and orthostatic positions. Echo-Doppler analysis evaluated the common carotid and popliteal arteries after blood pressure measurements. CWT was calculated according to Laplace s law. Changing from supine to orthostatic posture increased CWT in popliteal but not in carotid arteries. Partial correlation analysis controlled for age and body mass index revealed that supine and orthostatic CWT exhibited comparable correlation coefficients with carotid IMT, while orthostatic CWT displayed a stronger relationship with popliteal IMT than supine CWT. These results were further confirmed by multiple linear regression analysis including age, sex, body mass index, lipid fractions and glucose as independent variables. Orthostatic CWT is a better hemodynamic predictor of popliteal IMT in comparison to supine CWT. These data suggest that orthostatic posture may be a potential risk factor for popliteal atherosclerosis by increasing local hemodynamic burden

ASSUNTO(S)

arteria poplitea imt espessura intima-media arteria carotida carotid artery popliteal artery

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