In Vitro Antifungal Susceptibility of Cryptococcus gattii

AUTOR(ES)

Trilles, Luciana

FONTE

American Society for Microbiology

RESUMO

We have determined the in vitro susceptibilities of 57 strains of Cryptococcus gattii to nine antifungal agents and have compared the MICs for these strains with those for C. neoformans. MICs were determined by a microdilution reference method. Albaconazole and ravuconazole (MICs of 0.04 and 0.05 μg/ml, respectively) showed the best activities. Micafungin showed no activity (MIC of >128 μg/ml). In general, C. gattii was less susceptible than C. neoformans to all drugs tested, with the exception of amphotericin B and flucytosine.

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