In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis
AUTOR(ES)
Blanco, Odalys, Lugones, Yuliannis, Díaz, Elaine, Monzote, Lianet
FONTE
Revista do Instituto de Medicina Tropical de São Paulo
DATA DE PUBLICAÇÃO
2011-08
RESUMO
Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®.
Documentos Relacionados
- Influence of a Pulmonary Surfactant on the In Vitro Activity of Tobramycin against Pseudomonas aeruginosa
- Antiprotozoal Activity of the Cyclopalladated Complexes Against Leishmania amazonensis and Trypanosoma cruzi
- Activity of the Lupane isolated from Combretum leprosum against Leishmania amazonensis promastigotes
- In vitro activity of the hydroethanolic extract and biflavonoids isolated from Selaginella sellowii on Leishmania (Leishmania) amazonensis
- In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasi and L (Viannia) braziliensis
