In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

AUTOR(ES)

Lavorato, Stefânia Neiva, Sales Júnior, Policarpo Ademar, Murta, Silvane Maria Fonseca, Romanha, Alvaro José, Alves/, Ricardo José

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

29/05/2015

RESUMO

We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity.

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