Impacto da aplicação topica do gel doador de oxido nitrico no fluxo sanguineo clitoridiano, avaliado pelo ultra-som Doppler / The impact of the topic administration of a nitric oxide donor gel in the blood flow of the clitoris using the Doppler ultrasound

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Introduction Sex is a part of the daily life of people and it is not just limited to conception. Different factors may inhibit female s sexual response, in a transitory or prolonged way. The sexual response is affected by age, tobacco, cholesterol, hypertension and diabetes. It is a multifactor condition, with anatomical, physiological, medical, psychological and social factors. (Wyman JF; et al, 1987) The increase of blood flow in the clitoris is due to sexual stimulation, being a part of the female s sexual response. (Levin RJ, 1980) That makes it a good way to asses a treatment for female sexual dysfunction. The nitric oxide (NO) and intestinal vase active peptides are involved in the ingurgitation of clitoridean tissue after sexual stimulation. The nitric oxide is one of the smallest and most simple biosynthesized molecules, and it is a gaseous, inorganic, colorless free radical, with seven electrons from nitrogen and eight from oxygen, and one oxygen electron is uneven. (Beckman JS &Koppenol WH, 1996) Objective Evaluate through the Doppler ultra-sound if the topic use of a nitric oxide donor gel would increase the blood flow in the clitoris of healthy women. Materials and method In this study we evaluated twenty healthy women who underwent ultrasound of the clitoris artery, comparing the normal blood flow and the flow with the use of the gel. The hemodynamic analysis considered: systolic peak speed, diastolic speed and vase resistance index. Results In the statistical analysis we found significant statistical differences in all the parameters measured (p <0,05). The mean initial systolic speed was 104 and after the gel use it was 109 (p=0,002). The mean initial diastolic speed was 107 and with Abstract the gel it was 106 (p=0,043) and the mean initial resistance was 105 and after the use of the gel it was 107 (p=0,005). Conclusion The use of the topic gel proved to be effective to increase the blood flow in the area of the clitoris

ASSUNTO(S)

blood flow physiological sexual dysfunction oxido nitrico nitric oxide disfunção sexual fisiologica fluxo sanguineo

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