Immunohistochemical changes in morphologically involved and uninvolved colonic mucosa of patients with idiopathic proctitis.
AUTOR(ES)
Das, K M
RESUMO
Alterations in secretory component, IgA, IgG, and IgM were studied by immunofluorescent techniques in mucosal biopsy specimens obtained at colonoscopy from inflamed and grossly uninvolved colonic mucosa from 12 patients with idiopathic proctitis. Parotid-salivary secretory component and IgA and serum immunoglobulins were also investigated. Decreased secretory IgA was observed in the epithelium of all grossly involved rectal mucosa and in 40% of proximal normal mucosa. Salivary secretory IgA was not diminished. These observations suggest that a local immune defect may be pathogenetically related to idiopathic proctitis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=333372Documentos Relacionados
- Proliferation rate of colonic mucosa in normal subjects and patients with colonic neoplasms: a refined immunohistochemical method.
- Immunohistochemical detection of abnormal cell proliferation in colonic mucosa of subjects with polyps.
- Aseptic meningitis and herpes simplex proctitis. A case report.
- Immunohistochemical demonstration of pancreatic secretory trypsin inhibitor in normal and neoplastic colonic mucosa.
- Morphological and mucus secretion criteria for differential diagnosis of solitary ulcer syndrome and non-specific proctitis.