Immunogenicity of group B Streptococcus type III polysaccharide-tetanus toxoid vaccine in baboons.
AUTOR(ES)
Paoletti, L C
RESUMO
Maternal vaccination has been proposed as a rational approach for the prevention of neonatal group B streptococcal (GBS) disease. In this study, baboons were used as a nonhuman primate model to evaluate the immunogenicity of a GBS type III glycoconjugate vaccine. Type III-specific immunoglobulin G with opsonic activity was induced after vaccination with type III polysaccharide coupled to tetanus toxoid administered with an aluminum adjuvant. This suggests that baboons could be used in evaluating maternal transfer of GBS-specific antibodies by vaccination during pregnancy.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=173821Documentos Relacionados
- Group B Streptococcus type II polysaccharide-tetanus toxoid conjugate vaccine.
- Immune response to type III group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine.
- Stimulation of protective antibodies against type Ia and Ib group B streptococci by a type Ia polysaccharide-tetanus toxoid conjugate vaccine.
- Immunological evaluation of meningococcal group C polysaccharide-tetanus toxoid conjugate in mice.
- Immune responses of young mice to pneumococcal type 9V polysaccharide-tetanus toxoid conjugate.