Immunity against infection with Trypanosoma cruzi in mice correlates with presence of antibodies against three trypomastigote polypeptides.
AUTOR(ES)
Zweerink, H J
RESUMO
Repeated immunizations of CF1 mice with irradiated noninfectious Trypanosoma cruzi trypomastigotes resulted in partial protection against infection with live parasites. It also induced a limited number of antibody species that were reactive in Western blots with trypomastigote but not with epimastigote or amastigote polypeptides. These antibody species were strongly reactive with a 100,000-dalton polypeptide and much less reactive with at least two polypeptides greater than 200,000 daltons. Immunization with epimastigotes induced antibodies against a 57,000-dalton epimastigote-specific polypeptide but did not induce protective immunity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=261620Documentos Relacionados
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