Idiopathic interstitial pneumonias : of the pathogenesis and remodeling to anatomic-physician-radiological determinatives of prognostic and survival with emphasis to the vascular component / "Pneumonias intersticiais idiopáticas: da patogênese e do remodelamento aos determinantes anátomo-clínico-radiológicos de prognóstico e sobrevida com ênfase ao componente vascular"

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Studied for morphology, morphometry and immunohischemistry the vascular (adhesion molecules), epithelial (adhesion molecules) and interstitial (collagen V and immune cells) remodeling in the three major types of idiopathic interstitial pneumonias: in 62 cases of IPF, 22 cases of NSIP, and 25 cases of AIP. The impact of these alterations was evaluated in the function tests, survival and prognostic. We demonstrated that the active and fibroelastotic vascular remodeling is directly proportional to the degree of parenchymal activity, mainly in the UIP. Collagen V, mapping of the immune cells, increase of the endothelial and epithelial activity had possibly impact in the distinguishing specter and in pathogenesis of the three interstitial pneumonias studied. The cellular immune reply in the UIP it had impact in survival of the patients

ASSUNTO(S)

colágeno tipo v prognosis blood vessels/injuries lung diseases interstitial vasos sangüíneos/lesões inflamação fibrose pulmonar survival sobrevivência imunohistoquímica extracellular matrix inflammation immunohistochemistry prognóstico doenças pulmonares intersticiais pulmonary fibrosis matriz extracelular collagen type v

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