Identification of a Bovine Coronavirus Packaging Signal
AUTOR(ES)
Cologna, Raymond
FONTE
American Society for Microbiology
RESUMO
A region of the bovine coronavirus (BCV) genome that functions as a packaging signal has been cloned. The 291-nucleotide clone shares 72% homology with the region of mouse hepatitis coronavirus (MHV) gene 1b that contains the packaging signal. RNA transcripts were packaged into both BCV and MHV virions when the cloned region was appended to a noncoronavirus RNA. This is the first identification of a BCV packaging signal. The data demonstrate that the BCV genome contains a sequence that is conserved at both the sequence and functional levels, thus broadening our insight into coronavirus packaging.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=111575Documentos Relacionados
- Identification and characterization of a coronavirus packaging signal.
- Murine coronavirus packaging signal confers packaging to nonviral RNA.
- Cooperation of an RNA Packaging Signal and a Viral Envelope Protein in Coronavirus RNA Packaging
- Analysis of efficiently packaged defective interfering RNAs of murine coronavirus: localization of a possible RNA-packaging signal.
- Transmissible Gastroenteritis Coronavirus Packaging Signal Is Located at the 5′ End of the Virus Genome