Histomorphometric comparative study of collagen and elastin in human abdominal skin of massive weight loss patient / Estudo histomorfométrico comparativo do colágeno e elastina na pele abdominal humana após perda ponderal maciça

AUTOR(ES)

Simone Cristina Orpheu

DATA DE PUBLICAÇÃO

2009

RESUMO

Morbid obesity is an increasing health problem and it is defined as a body mass index greater than 35 kg/m² with severe obesity related comorbidity or a body mass index greater than 40 kg/m² without comorbidity. The combined direct and indirect cost of obesity has been elevated. Bariatric surgery remains the only durable option for weight loss in the morbidly obese.Advanced laparoscopy procedures, as less invasive therapy, have contributed to fast recovery and acceptable perioperative morbidity. Results of bariatric surgery can reach about 50% of excess weight loss with a 2 year follow-up. As patients lose weight, they get laxity skin and their interest in body contouring surgery begins.Plastic surgery in massive weight loss patient demands attention to reduce risks and viable expectations concern to aesthetic results. However, after body contouring surgery, patients can keep up some laxity or folds of excess skin. Obesity changes the components of skin, but there arent definitive studies about skin in massive weight loss patients. In this histomorphometric comparative study, biopsies of human female abdominal skin were analysed in quantity of collagen and elastic fibers in controls (non obese patients, epigastric topography n=15 and hypogastric topography n=25 ) in comparison to massive weight loss patients (n=40). After statistical analyses with p<0,05 was demonstrated that: a)in epigastric topography, the quantity of collagen was higher in control group; b) in epigastric topography, the quantity of elastic fibers was higher in case group; c) in hypogastric topography, there werent diferences in the quantity of collagen between cases and controls; d) in hypogastric topography, the quantity of elastic fibers was higher in control group

ASSUNTO(S)

bariatric surgery elastina abdome cirurgia bariátrica lipectomy elastin lipectomia pele/anatomia &histologia morbid obesity skin/anatomy&histology abdomen collagen colágeno obesidade mórbida

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