High-frequency transduction of c-erbB in avian leukosis virus-induced erythroblastosis.
AUTOR(ES)
Miles, B D
RESUMO
Twenty-one cases of Rous-associated virus type 1-induced erythroblastosis have been analyzed for novel restriction endonuclease fragments of c-erbB. Twenty of the erythroleukemias contained novel c-erbB fragments; 10 of these were found to contain a proviral insertion in c-erbB, and 10 were found to have a new transduction of c-erbB. Each of the proviral insertions was in the same transcriptional orientation as c-erbB, and most appeared to have retained both long terminal repeats as well as 5' viral sequences that signal packaging of RNA into virions. Each of the new c-erbB transducing viruses had a characteristic EcoRI fragment that contained a spliced form of c-erbB sequences. When inoculated into 1-week-old chickens, the new transducing viruses caused rapid-onset erythroblastosis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254797Documentos Relacionados
- c-erbB activation in avian leukosis virus-induced erythroblastosis: clustered integration sites and the arrangement of provirus in the c-erbB alleles.
- Activation of c-erbB in avian leukosis virus-induced erythroblastosis leads to the expression of a truncated EGF receptor kinase.
- c-erbB activation in avian leukosis virus-induced erythroblastosis: multiple epidermal growth factor receptor mRNAs are generated by alternative RNA processing.
- Differential Selection of Cells with Proviral c-myc and c-erbB Integrations after Avian Leukosis Virus Infection
- Infrequent involvement of c-fos in avian leukosis virus-induced nephroblastoma.