Hepatitis A: the costs and benefits of the disease prevention by vaccine, Paraná, Brazil
AUTOR(ES)
Zahdi, Mariana Ribas, Maluf Junior, Ivan, Maluf, Eliane Mara Cesário Pereira
FONTE
Brazilian Journal of Infectious Diseases
DATA DE PUBLICAÇÃO
2009-08
RESUMO
This study evaluated the epidemiological behavior of the hepatitis A in Paraná state and compared the costs of the disease and the vaccination. This is an epidemiological descriptive study including a pharmacoeconomy analysis. We collected information in the national database reported cases (SINAN), in the mortality information system (SIM) and in the hospital information system (AIH) among 2000/2003 (Paraná State Public Health Department). We estimated the probability of one cohort of children to acquire hepatitis A during their lifetime and the costs with their treatment. We compared those costs with the cost of vaccinating the children. 14,682 hepatitis A cases were registered during the period studied, and 12,102 (82.4%) occurred in the 0-15 years-old age group. The annual incidence in the general population was 37.5/100,000. We observed 20 deaths caused by this disease; 7 of those occurred by liver failure. The estimated costs with the disease included the hospital costs, liver transplantation, liver failure treatment, and laboratory tests were high. The price of the vaccine is 10 USD/dose. Two doses are necessary to get the protection. The results showed a positive cost - benefit relation when we vaccinate children. We save 2.26 USD in treatment for each dollar invested in the vaccine. Paraná record high number of hepatitis A cases each year. We confirmed the positive cost - benefit relation when we vaccinate children against hepatitis A, reducing suffering, hospitalization, death and social costs. Vaccination against hepatitis A should be recommended in the routine of immunization program in Paraná state.
Documentos Relacionados
- Hepatitis B virus, the vaccine, and the control of primary cancer of the liver*
- Hepatitis A: a Kupffer cell disease?
- Costs and benefits of eliminating child labour in Brazil
- Evaluation of the water quality of tidal creeks of Pontal do Paraná, Paraná, Brazil
- Epidemiological and clinical profile of patients with Chagas disease in the Central-North area of Paraná, Southern Brazil