Genetics of natural resistance to Sendai virus infection in mice.
AUTOR(ES)
Brownstein, D G
RESUMO
The genetics of resistance to a naturally occurring respiratory infection caused by Sendai virus was examined in F1, F2, and backcross progeny of resistant C57BL/6J and susceptible DBA/2J mice and in 25 recombinant inbred strains. An intranasal inoculum of 0.1 50% tissue culture infective dose (low dose) of Sendai virus caused 0% mortality in C57BL/6J and F1 mice and 73% mortality in DBA/2J mice. An inoculum of 1.0 50% tissue culture infective dose (high dose) caused 3, 0, and 89% mortality in C57BL/6J, F1, and DBA/2J mice, respectively. Low-dose infection caused 36% mortality in F1 X DBA/2J hybrids and 0% mortality in F2 hybrids. High-dose infection caused 29 and 32% mortality in F1 X DBA/2J and F2 hybrids, respectively. Resistance was not linked to H-2 haplotype, coat color, or sex. High-dose infection caused deaths in 12 recombinant inbred strains, and the strain distribution pattern was concordant with that of a chromosome 1 marker, Sas-1, in 20 of 25 strains (P less than 0.01). Resistance therefore behaved as a simple Mendelian dominant trait which presumptively mapped to chromosome 1.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=264779Documentos Relacionados
- Cell-mediated immunity to Sendai virus infection in mice.
- Pathogenesis of Sendai virus infection in the central nervous system of mice.
- Genetics of macrophage-controlled resistance to hepatitis induced by herpes simplex virus type 2 in mice.
- Mechanisms determining innate resistance to ectromelia virus infection in C57BL mice.
- Host defenses in experimental rickettsialpox: genetics of natural resistance to infection.