Genetic epidemiology of malaria infection at Rondônia. / Genética epidemiológica de malária em Rondônia.
AUTOR(ES)
Ricardo de Godoi Mattos Ferreira
DATA DE PUBLICAÇÃO
2008
RESUMO
With the aim of investigate the genetic mechanisms related to the human response to malaria infection, two Amazonian populations were studied. About 180 individuals from Portuchuelo population and more than 800 individuals from Monte Negro were included in the sample. Those individuals where subjected to an epidemiological survey, followed by characterization of genetic markers. Among the characteristics surveyed, the number of malaria episodes reported by the subjects was tested for association with classic blood groups markers after correction for age and sex. The expected association with Fy- individuals was observed in both populations, without significant heterogeneity. Complex segregation analyses indicated the presence of a major gene related to the number of malaria episodes. A genomic scan using STRs markers was conducted at the Portuchuelo sample. The multipoint linkage scan showed a lod score suggestive of linkage at the short arm of chromosome 4. The results found at Portuchuelo were not confirmed at the Monte Negro sample using 9 STRs.
ASSUNTO(S)
polymorfism population genetics polimorfismo malaria malária bioestatistica biostatistics epidemiology epidemiologia genética de populações
