Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.
AUTOR(ES)
Rodriguez, M
RESUMO
Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=189655Documentos Relacionados
- Transgenic Expression of Theiler's Murine Encephalomyelitis Virus Genes in H-2b Mice Inhibits Resistance to Virus-Induced Demyelination
- Promotion of remyelination by polyclonal immunoglobulin in Theiler's virus-induced demyelination and in multiple sclerosis.
- Strains from both Theiler's virus subgroups encode a determinant for demyelination.
- Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination.
- Theiler's murine encephalomyelitis virus-induced cardiac and skeletal muscle disease.