Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease
AUTOR(ES)
Oliveira, Aldo S.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
08/04/2019
RESUMO
We report a series of functionalized dienes as compounds of great potential in the treatment of Alzheimer’s disease due to their antioxidant activity and ability to inhibit the enzyme acetylcholinesterase. The dienes tested showed high enzymatic inhibition capacity and accentuated antioxidant activity, which are comparable to or higher than the standards tested. Molecular docking studies were performed to confirm the experimental results. We also describe the correlation values between the antioxidant activity and oxidation potentials. Predicted bioactivity scores and quantum studies were also determined.
Documentos Relacionados
- Series Introduction: Alzheimer’s disease: perspectives for the new millennium
- BOOK REVIEWS: Alzheimer's Disease—New Treatment Strategies (Dementia Reviews Series/1).
- Anti-amyloid agents for treating incipient Alzheimer’s disease: a new hope?
- Treatment of Alzheimer's disease.
- New Concepts in Alzheimer's Disease. (Pierre Fabre Monograph Series Vol 1.)