From sequence to structure and back again: approaches for predicting protein-DNA binding

AUTOR(ES)

Höglund, Annette

FONTE

BioMed Central

RESUMO

Gene regulation in higher organisms is achieved by a complex network of transcription factors (TFs). Modulating gene expression and exploring gene function are major aims in molecular biology. Furthermore, the identification of putative target genes for a certain TF serve as powerful tools for specific targeting of rational drugs.

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