Fibromatose gengival hereditaria : aspectos morfologicos e ultraestruturais

AUTOR(ES)
DATA DE PUBLICAÇÃO

1991

RESUMO

The ultrastructure of the gingival connective tissue was analysed in 12 patients bearing Hereditary Gingival Fibromatosis (H.G.F.) and compared with normal gingival tis sue from biopsies of 08 volunteers. Some fibroblasts appeared as normal cells, but most of these cells showed minor to severe altered features, up to signs of cell desintegration the main alterations were: 1) enlarged R.E.R. cisternaes, filled with fine granular or flocular material; 2) vaeuolization of mitochondrias, loosing their internal structure and some filled with very dense material; 3)vesicles with dense content or with dense cores; 4) cells showing broken-off menbrane releasing their content into the extracellular matrix. The extracelular matrix showed a predominance of collagen fibers most of them with normal structure, but in some areas fibers with a tortuous cours,e and/or variable diameter were seen. Variable size of the interfiber space wàs also a common feature. Elastic fibers were scarce and in some areas, amorphus flocular material besides cells debris were predominant. Amyloid material was not identified and a increase in number of oxytalan fibers was showed. Both results were confirmed by light microscopy observations of gingival sections stained with either congo red for amyloid or peracetic acid and aldehyde-fuchsin for oxytalan fiber. Some of such ultrastructural features were comparable with the ones described in relation of various hereditary diseases characterized by skin connective tissue disorders.

ASSUNTO(S)

patologia bucal

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