Fatores coadjuvantes no agravamento da mucosite oral radioinduzida

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Objectives: Identify risk factors related to the aggravation of radiotherapy-induced oral mucositis. Methods: The sample was made up of 33 patients with malignant head and neck tumors submitted to radiotherapy. Data were collected on age, gender, histological type of tumor, stage, location, oral hygiene habits, smoking habits, alcohol intake, general health state, dose and type of radiation, swab collection for DNA detection of HSV 1 virus through PCR. Patients were examined starting with the second week of treatment, followed up on a weekly basis until the end of the applications and classified based on the World Health Organization criteria for oral mucositis. Data were statistically analyzed to correlate the degree of mucositis with the factors considered. Results: There was no clinical evidence of mucositis in 6.1% of the patients; 24.2% had Grade I mucositis; 33.3% had Grade II; 33.3% had Grade III; and 3.0% had Grade IV. The degree of mucositis was more intense among older patients, the female gender and those receiving 200 cGy through electron radiotherapy. Only one patient tested positive for HSV 1. None of the data indicated a statistically significant correlation with the patientâs degree of mucositis. Conclusion: For the sample analyzed, risk factors such as age, gender, dose and type of radiation, general health state, oral hygiene habits and HSV 1 infections demonstrated no statistically significant correlation with the aggravation of radio-induced oral mucositis

ASSUNTO(S)

herpes simplex virus 1 oral tumors oral mucositis odontologia radiotherapy mucosite oral neoplasias bucais herpesvirus 1 humano radioterapia

ACESSO AO ARTIGO

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