Extratos de Arrabidaea chica (Humb. &Bonpl.) verlot obtidos por processos biotecnológicos: otimização da extração e avaliação farmacológica. / Arrabidaea chica (Humb. &Bonpl.) Verlot extracts obtained by biotechnological processes: extraction optimization and pharmacological evaluation.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Arrabidaea chica Verlot (Bignoniaceae), known as crajiru, produces red pigments used by Brazilian indians as dye and as healing agent. This study has aimed the optimization of phenolic compounds extraction from A. chica and to evaluate its pharmacological activities. Extracts from A. chica were obtained through treatment with xylanases from Bacillus pumilus before the extraction. The assays were monitored by HPLC and ESI/MS-MS. The enzymatic treatment has produced more concentrated in anthocyanidins extracts. Those obtained without enzymatic treatment have presented higher glycosilated anthocyanins content. The pharmacologic study has demonstrated that the antitumoral and the antioxydant in vitro properties for A. chica are directly related to the higher contents of aglycones. In vitro assay for fibroblasts growth induction has demonstrated that a higher content of carajurin is inversely proportional to the healing action. In conclusion, a novel approach has been developed, through biotechnological process, aiming the extraction of anthocyanidins presenting dye and therapeutic properties.

ASSUNTO(S)

antioxidant capacity biotecnologia corantes (extração) arrabidaea chica dyes (extraction) capacidade antioxidante poliovirus bacullus pumilus cicatrização biotechnology bacullus pumilus arrabidaea chica poliovírus antineoplásicos healing antineoplastics

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