Experimental Porphyromonas gingivalis infection in nonimmune athymic BALB/c mice.
AUTOR(ES)
Chen, P B
RESUMO
The purpose of this report was to study the role of T lymphocytes following injection of Porphyromonas gingivalis in a mouse abscess model. Three invasive P. gingivalis isolates (ATCC 53977, W83, and AJW4) were injected into athymic BALB/c mice and their heterozygous (nu/+) littermates. The athymic BALB/c (nu/nu) mice were able to localize the invasive P. gingivalis isolates at the injection site. By comparison, the heterozygous BALB/c (nu/+) littermates developed hemorrhagic secondary lesions within 24 h after subcutaneous injection of the same invasive P. gingivalis isolates. These results suggest that naive T lymphocytes may contribute to the pathology associated with P. gingivalis infection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=259103Documentos Relacionados
- Experimental production of actinomycetoma in BALB/c mice.
- Gamma interferon controls Eimeria vermiformis primary infection in BALB/c mice.
- Gastrointestinal microecology of BALB/c nude mice.
- Experimental intrauterine infection of adult BALB/c mice with Cryptosporidium sp.
- Vaccine-induced immunity against cutaneous leishmaniasis in BALB/c mice.