Evolução das mutações de resistência aos inibidores de protease em pacientes infectados pelo HIV-1 subtipo F / Evolution of protease inhibitor resistance mutations in HIV-1 subtype F infected patients

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The high genetic variability of HIV type 1 and the selection of antiretroviral resistance mutations have represented an enormous challenge to therapeutic schema success. Many studies have demonstrated that there are specific mutations patterns for each of the HIV-1 subtypes. Subtype B mutation profiles are the best studied due to its high presence in Europe and USA epidemics. However, prevalence of non-B subtypes, as well as recombinant forms, has been significantly increasing in many regions. In Brazil, where subtypes B and F, and in some states also C, have been co-circulating, BF recombinants are commonly found. The aims of this work were to compare protease region of BF recombinants to pure subtype F to search for different amino acid substitutions; analyzing mutation profile and co-variation of related-to-treatment mutations; verifying the relationship between the presence of groups of mutations and the use of specific antiretroviral drugs; and evaluating the selection of new mutations after changing therapeutic schema

ASSUNTO(S)

epidemiologia e bioestatistica hiv-1 drug resistance molecular epidemiology epidemiology and biostatistics epidemiologia molecular hiv-1 resistência aos medicamentos

ACESSO AO ARTIGO

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